摘要
目的:探讨LMWH治疗重症急性胰腺炎的机理。方法:建立假手术组(S组)、重症急性胰腺炎组(SAP组)和LMWH治疗组(H组),比较各组死亡率、血清淀粉酶、IL-6、ET和NO水平。结果:H组死亡率、血清淀粉酶、IL-6和ET明显低于SAP组(P<0.001)。H组NO明显高于SAP组(P<0.001)。结论:LMWH可能通过降低内皮素水平,提高NO水平,从而改善胰腺血循环,减少炎症介质的释放,减轻SAP的炎症程度。
Objective：To explore the mechanism of low molecular weight heparin （LMWH） for severe acute pancreatitis （SAP）. Methods ：48 wistar rats were randomly divided into 3 groups：sham operative group（S group）, severe acute pancreatitis group（SAP group） and LMWH therapy group （H group）. The serum amylase, IL-6 ,ET, NO were tested. Results：The value of amylase, ET,and IL-6 in SAP group was significantly higher than that in H group （P〈0.001）. The value of NO in H group was significantly higher than that in SAP group.Conclusion： LMWH therapy may ameliorate SAP by reducing the level of ET and increasing the level of NO.
出处
《现代医药卫生》
2008年第14期2065-2066,共2页
Journal of Modern Medicine & Health
关键词
胰腺炎
低分子量肝素
治疗
Pancreatitis
Low molecular weight heparin
Therapy
