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Rb1基因mRNA在人胃癌中表达的研究 被引量:2

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摘要 利用Rb1基因特异性cDNA探针,采用Northern杂交分析方法,检测16例经临床及病理确诊为胃癌的肿瘤组织及其癌旁组织标本中Rb1mRNNA的表达状态。2例(2/16)出现Rb1基因mRNA表达的缺失。提示:胃癌的发生可能与13号染色体的杂合性缺失及Rb1基因缺失有关。
出处 《实用肿瘤学杂志》 CAS 1997年第3期170-171,共2页 Practical Oncology Journal
基金 国家教委<国家优秀青年教师基金> 吉林省科委<青年基金>
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同被引文献16

  • 1吕有勇,高崇峰,崔建涛,孙梅程,金泉.胃癌中MTS1/p16基因缺失及表达异常的研究[J].中华肿瘤杂志,1996,18(3):189-191. 被引量:88
  • 2[1]Mate JL,Ariza A.Cyclin D1 overexpression in non-small cell lung carcinoma:Correlation with Ki67 labelling index and poor cytoplasmic differentiation.J Pathol,1996;180:395-399
  • 3[2]Kamb A,Gruis NA,Weaver-Feldhaus J,Liu Q,Harshman K,Tavitigia SV,Day RS,Johnson BE,Skolnick MH.A cell cycle regulatoer potentially involved in the genesis of many tumor types.Science,1994; 264:436 - 440
  • 4[7]Shapiro GI,Eddwards CD,Kobzik L,Godieski J,Richards W,Sugarbaker DJ,Rollins BJ.Reciprocal Rb inactivation and P16INK4 expression in primary lung cancer and cell lines.Cancer Res,1995; 55:505 - 509
  • 5[8]Yeager T,Studler W,Belair C,Puthenveettil J,Olopade O,Reznikofi C.Increased P16 levels correlate with pRb alterations in human urothelial cells.Cancer Res,1995; 55:493 - 496
  • 6[9]Herman JG,Merlo A,Mao L,Lapidus RG,Issa JPJ,Davidson NE,Sidransky D,Baylin SB.Inactivation of the CDKN2/P16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.Cancer Res,1995; 55:4525 - 4530
  • 7Tsh(o)p K,Conery AR,Litovchick L. A kinase shRNA screen links LATS2 and the pRB tumor suppressor[J].Genes and Development,2011,(08):814-830.
  • 8Kalungi S,Wabinga H,Bostad L. The RB (pRb2/p16) and p53 (p14/p53/p21) tumor-suppressor pathways in endemic Burkitt lymphoma[J].Journal of Pediatric Hematology Oncology,2011,(02):e54-e59.doi:10.1097/MPH.0b013e3181edf543.
  • 9Kheirollahi M,Mehr-Azin M,Kamalian N. Expression of cyclin D2,P53,Rb and ATM cell cycle genes in brain tumors[J].Medical Oncology,2011,(01):7-14.doi:10.1007/s12032-009-9412-8.
  • 10Gope R,Christensen MA,Thorson A. Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa[J].Journal of the National Cancer Institute,1990,(04):310-314.doi:10.1093/jnci/82.4.310.

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