颅脑损伤患者血浆NPY含量变化的观察

Observation on Changes of Plasma Neuropeptide Y Levels in Patients with Brain Injury

目的：分析颅脑损伤患者血浆神经肽Y（NPY）含量变化的临床意义。方法：按GCS评分，将101例颅脑损伤患者分三组：即轻度（13—15分）44例、中度（9—12分）27例和重度（3—8分）30例。采用放射免疫分析分别测定患者和30例正常对照组血浆NPY含量。按年龄分为：50岁以下、50岁及以上两组；按男女性别分两组；分别进行统计学分析。结果：颅脑损伤轻、中、重度患者血浆NPY含量均明显高于正常对照组，中度组明显高于轻度组，重度组明显高于中度组，病情越重升高越显著；50岁以下患者明显高于≥50岁患者；男、女性别之间比较差异无统计学意义。结论：血浆NPY含量测定有助于对颅脑损伤患者临床病情的评估和预后判定。

Objective To investigate the clinical significance of changes of plasma neuropeptide Y （NPY） levels in patients with brain injury. Methods 101 patients with brain injury were of three groups ： ① mild group （ n = 44, GCS 13 ～ 15）, moderate group（n =27,GCS9 ～ 12） and severe group（n =30）. Plasma NPY levels were detemined with RIA these in patients and 30 controls. Results The plasma NPY levels were significantly higher in the patients than those in the controls. The more severe the illness, the higher NPY levels were. The plasma NPY levels were significantly lower in patients under 50 years old than those in patents over 50 years old. There were no statistical differences between the NPY levels in male and female patients. Conclusion Plasma NPY levels might be useful for monitoring and outcome predicting in patients with brain injury,