妊高征患者血浆ET水平与红细胞膜ATP酶活性的改变与发生肾病的关系

Relationship Between Changes of Plasma Endothelin (ET) Level,ATPase Activity of Erythrocyte Membrane and Development of Nephropathy in Patients with Pregnancy Induced Hypertension

目的:探讨了妊高征肾病患者血浆内皮素(ET)水平和红细胞膜ATP酶活性的改变参与妊高征肾病的可能机制。方法:应用放射免疫分析和Reilni制膜法制定了32例妊高征肾病患者血浆ET水平和红细胞膜上Na+-K+-ATP酶和Ca2+-Mg2+-ATP酶活性的变化,并与70名妊高征无肾病组和35名正常孕妇作比较。结果:妊高征肾病组和无肾病组血浆ET水平非常显著地高于正常孕妇组(P<0.01),而红细胞膜上Na+-K+-ATP酶和Ca2+-Mg2+-ATP酶的活性均显著地低于正常孕妇组(P<0.01),妊征肾病组与无肾病组有显著性差异(P<0.05)。结论:妊高征肾病的发生与发展与血浆ET和红细胞膜上Na+-K+-ATP酶和Ca2+-Mg2+-ATP酶的活性有密切的关系。

Objective To investigate the possible role played by alteration of plasma ET levels and activities of Na^＋ - K^＋ - APT ase and Ca^2＋ - Mg^2＋ - ATPase of erythroeyte membrane in patients with nephropathy pregnancy induced hypertension. Methods The concentrations of plasma ET was detected with RIA and erythrocyte membrane ATPase activities were determined with Reilni method in 32 pregnant women with PIH complicated with nephropathy and 70 women with PIH but no nephropathy and 35 normal pregnant women as controls. Results The plasma ET levels in patients with PHI （both with and without nephropathy） were significantly higher than those in normal preganat women （P 〈 0.01 ）, while the Na^＋ -K^＋ -ATPase and Ca^2＋ - Mg^2＋ -ATPase levels were significantly decreased （ P 〈 0.01 ）. Amone the PHI patients, differences between the levels in the 2 subgroups （ with and without nephropathy were also significantly, P 〈 0.05）. Conclusion The development of pregnancy induced hypertensive nephropathy is correlated to the higher plasma ET levels and decreased Na^＋ - K^＋ - ATPase and Ca^2 ＋ - Mg^2 ＋ - ATPase activity of erythroeyte membrane.