乙型肝炎患者血清IGF-Ⅰ和血浆SS水平的变化及临床意义

Clinical Significance of Changes of Serum IGF-Ⅰ and Plasma SS Levels in Patients with Hepatitis B

目的:探讨了乙型肝炎患者血清胰岛素样生长因子-Ⅰ(IGF-Ⅰ)和血浆生长抑素(SS)水平的变化及临床意义。方法:应用放射免疫分析对95例乙型肝炎患者进行了血清IGF-Ⅰ和血浆SS含量测定,并与35例正常健康人作比较。结果:乙型肝炎患者血清IGF-Ⅰ和血浆SS水平均非常显著地高于正常人组(P<0.01),两者呈明显正相关(r=0.6018,P<0.01)。结论:检测乙型肝炎患者血清IGF-Ⅰ和血浆SS水平的变化对了解病情和预后密切相关,均有重要的临床价值。

Objective To study the clinical significance of changes of serum IGF - I and plasma SS levels in patients with hepatitis B. Methods Serum IGF - I and plasma SS levels were measured with RIA in 95 patients with hepatitis B and 35 controls. Results Serum IGF - I and plasma SS levels in the patients were significantly higher than those in the controls （P 〈 0.01 ） and the two were mutually positively correlated. Conclusion Determination of serum IGF - I and plasma SS contents might be of help in the assessment of disease process in patients with chronic hepatitis B.