血清脂联素测定在冠心病患者中的临床意义

Clinical Significance of Determination of Serum Adiponectin Concentrations in Patients with Coronary Heart Disease

目的:探讨血清脂联素测定在冠心病患者中的临床意义。方法:采用ELISA分别检测了102例冠心病患者(稳定型心绞痛37例、不稳定型心绞痛31例、急性心肌梗死34例)及30例健康体检者血清脂联素水平。结果:冠心病患者血清脂联素水平明显低于正常对照组(P<0.01),急性心肌梗死患者血清脂联素水平明显低于不稳定型心绞痛和稳定型心绞痛(P<0.05,P<0.01);不稳定型心绞痛组与稳定型心绞痛组比较无显著性差异(P>0.05)。结论:血清脂联素水平下降与冠心病具有一定相关性,可作为冠心病患者病情变化的标志之一。

Objective To investigate the clinical significance of changes of serum adipanectin concentrations in patients with coronary heart disease（CHD）. Methods Serum concentxations of adiponectin were determined with ELISA in 30 controls（n =30） and 102 patients with coronary heart disease stable angina pectoris （ SAP n = 37） unstable angina pectoris （ UAP n = 31 ） and acute myocardial infarction （AMI n = 34）. Results Serum adiponectin concentrations were significantly lower in CHD patients than those in con- lxols （P 〈 0.01 ）. The levels in patients with AMI patients were significantly lower than those in patients with SAP and UAP （P 〈 0.05 and P 〈 0. 01 ）. However, there were no significant differences between the serum adipaneetin concentxations in SAP and UAP patients （P 〉 0.05 ）. Conclusion Lower circulating concentration of adipanectin was associated with higher risk of CHD and adiopenectin may serve as a risk marker of the disease.