钍稀土混合粉尘作业工人血清抗氧化酶活力和丙二醛含量变化

Changes of antioxidase and malondialdehyde in serum of workers occupationally exposed to thorium rare earth mixture dust

目的探讨钍稀土混合粉尘对作业工人血清某些抗氧化酶指标和丙二醛(MDA)的影响。方法采用分光光度法分析血清MDA含量、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和过氧化物酶(POD)活力。结果接尘组血清MDA含量[(9.74±3.60)μmol/L]显著高于对照组[(6.90±2.87)μmol/L,P<0.001],抗氧化酶POD[(10.65±5.94)×103U/L]显著低于对照组[(22.73±11.64)×103U/L,P<0.001],SOD和CAT与对照组比较差异无统计学意义。接尘组MDA含量与工龄呈正相关(r=0.248,P=0.038)。结论职业接触钍稀土混合粉尘者血清MDA水平升高,而POD活力下降。

Objective To investigate the changes of antioxidase and malondialdehyde in serum of workers occupationally exposed to thorium and rare earth mixture dust. Methods The concentration of malondialdehyde （ MDA）, activities of superoxide dismutase （SOD）, catalase （CAT）, and peroxidase （POD） in serum of peripheral blood were respectively examined by a spectrophotometer. Results The concentrations of MDA[ （9. 74 ± 3. 60） μmol/L] were higher in dust-exposed group than those in the control group [ （6.90 ± 2. 87 ） μmol/L, P 〈 0. 001 ]. The concentrations of MDA in dust-exposed group increased with working ages （r = 0. 248, P = 0. 038 ）. The activities of POD [ （ 10. 65± 5.94）×10^3 U/L] were lower in dust-exposed group than those in the control group [ （22. 73 ±11.64）×10^3 U/L,P 〈0. 001 ]. No differences were found in the activities of SOD and CAT between these two groups. Conclusion The thorium rare earth mixture dust could induce the increase of MDA level and the decrease of POD activity of serum in workers occupationally exposed to dust.