血清铁蛋白在儿童Still病中的临床意义

Clinical significance of serum ferritin in children with Still＇s disease

目的探讨血清铁蛋白（SF）在儿童Still病中的临床价值。方法回顾性分析我院2001年1月至2007年8月诊治的儿童Still病28例，分析患儿的临床特征、生化指标、血沉、SF,并与对照组34例（系统性红斑狼疮及上呼吸道感染发热的病例）进行SF比较。结果28例Still病中发热28例（100％），皮疹14例（50％），关节炎和关节疼痛18例（64％），白细胞升高24例（86％），血沉增快27例（96％），SF升高27例（96％）。Still病患儿SF平均值为（8182±3156）μg／L，较对照组（244±210）μg／L明显升高（P〈0．01）。结论发热、皮疹、关节疼痛和白细胞升高是儿童Still病的主要临床特点，SF可作为疾病活动期的指标。

Objective To investigate the clinical significance of serum ferritin （SF） in child with Still＇ s disease （SD）. Methods This study included 28 children with SD who were treated at the Pediatric Department in the First Hospital of China Medical University from 2001 to 2007. Their clinical features, biochemical parameters, and the results of serum ferritin were noted. Results In SD group, there were 28 cases with fever （ 100 % ）, 14 cases with rash （ 50 % ）, 18 cases with avthritis/arthralgia （ 64 % ）, 24 cases with leukocytosis （86%）,27 cases with SF and ESR elevation （96%）.The average SF in SD group [（8 182 ± 3 156） μg/L] was significantly higher than that in the control group [ （244 ± 210） μg/L] （ P （ 0.01 ）. Conclusion Fever, rash, arthritis/arthralgia, and leukocytosis are main clinical characteristics of child SD. Inereasing serum level of ferritin will probably indicate the activity period of SD.