西替利嗪的抗组胺作用

ANTIHISTAMINE EFFECT OF DOMESTIC CETIRIZINE

观察西替利嗪（cetirizine）对组险的阻断作用。分析pA2（拮抗指数），及对组胺致大鼠皮肤血管通透性增高和致豚鼠休克的影响。结果表明：西替利嗪为一竞争性H1受体拮抗剂．pA2为6．95，95％可信限为6．95±0．18；西替利嗪明显对抗组胺引起的皮肤血管通透性的增高，大中小剂量组的作用均优于扑尔敏；显著延长组胶静注致豚鼠呼吸加快的潜伏期，大中剂量组的作用优于扑尔敏，小剂量组与扑尔敏相当，且可完全阻止组胺林克的发生。结果提示：西替利嗪为一强效竞争性H1受体阻断剂。

To investigate the antihistamine action of domestic cetirizine, histanmine-induced skinreaction and shock model were employed, and its pA2 was analysed. The results showed that cetirizineeffectively antagonized the action of histamine that results in increased capillary permeability, andmuch effectively protected guinea-pig from histamine-inducd death, and the pA2 of cetirizine was 6.95. These findings suggest that domestic cetirizine is an effective and competitive H1 receptor antagonist.