山豆根水提物抗炎作用研究

Anti-inflammatory Effect of the Aqueous Extracts from Sophorae Tonkinensison

目的:研究山豆根水提物的抗炎作用。方法:复制二甲苯致小鼠耳肿胀测定各组鼠耳肿胀度;复制小鼠实验性腹膜炎及大鼠皮肤炎症模型,测定各组动物腹腔渗出液吸收度值;比较山豆根水提物与正常对照、氢化可的松组的模型动物耳肿胀度、毛细血管通透性。结果:山豆根水提物高、中剂量组能降低二甲苯致小鼠耳肿胀度;对小鼠实验性腹膜炎及大鼠实验性皮肤炎症有显著的抑制作用(P<0.01);山豆根水提物高、中剂量组与正常对照组比较有显著性差异(P<0.01)。结论:山豆根水提取物具有抗炎作用。

OBJECTIVE： To study the anti- inflammatory effect of the aqueous extracts of Sophorae tonkinensison. METHODS： The auricle edema was induced by xylene in the mice to measure the swelling of ear; the experimental peritonitis of mice and scytitis of rats were induced to measure the absorbability of the effusion. The ear swelling and capillary permeability in drug - treated group was compared with those in the normal control group and hydrocortisone - intervented model group.RESULTS： Mice＇s swelling induced by xylene was lessened by aqueous extracts of Sophorae tonkinensison （high or medium dose）, which also showed remarkable inhibitory effects on the experimental peritonitis of mice and seytitis of rats （P（0.01）. There were significant differences between aqueous extract of Sophorae tonkinensison （high or medium dose） treated group and normal control group （P〈0.01） . CONCLUSION： The aqueous extracts of Sophorae tonkinensison posess anti inflammatory effect.