摘要
目的:研究远志的抗抑郁活性成分。方法:用色谱法分离远志的化学成分,根据波谱学分析鉴定了化合物的结构,用MTT法评价其细胞毒活性。结果从远志分离得到8个化合物,分别鉴定为:西伯利亚远志糖A1(sibiricose A1,1),西伯利亚远志糖A5(sibiricose A5,2),tenuifoliside A(3),西伯利亚远志糖A6(sibiricose A6,4),3,4,5-三甲氧基肉桂酸甲酯(3,4,5-trimethoxycinnamate,5),远志酮Ⅲ(polygalaxanthoneⅢ,6),tenuifolioses A(7),tenuifolioses H(8)。结论:化合物1为首次从远志中分离得到,远志中的寡糖酯类成分对谷氨酸造成的PC12细胞损伤均有一定的保护作用。
Objective: To investigate the antidepressant components of Polygala tenuifolia. Method: The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities. Result: Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone Ⅲ (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds'activities to PC12 were observed. Conclusion: Compound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2008年第11期1278-1280,共3页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30572354)
关键词
远志
寡糖酯
PCI2细胞
抗抑郁
Polygala tenuifolia
sucrose ester
PC 12 cell
antidepressant