日本汉方药治疗慢性肾脏病研究的进展

Progress in Japanese herbal medicine in treatment of chronic kidney disease

慢性肾脏病(chronic kidney disease,CKD)已成为世界范围内危害公众健康的疾病。在日本,柴苓汤和温脾汤是治疗CKD的常用汉方药。文章综述了柴苓汤和温脾汤等汉方药对CKD进展过程中各种肾损害的保护作用,包括改善系膜组织损伤,减轻炎症细胞浸润,减少炎症介质表达,清除氧化应激产物,调节醛固酮代谢等作用,并且,在分子水平阐明了这些药物对各种损伤因子的作用机制。柴苓汤和温脾汤都是延缓CKD进展的有效药物。

In Japan, Saireito and Onpi-to are widely used Japanese herbal medicine in the treatment of chronic kidney disease （CKD） , which is a world-wide public health issue. In this review, it has been discussed the beneficial effects of Japanese herbal medicine, including Sairei-to and Onpi-to on multifarious renal damage in progression of CKD, such as mesangial lesion, inflammatory cell infiltration, cytokine expression, reactive oxygen species release, and aldosterone disorder, and then to clarify the mechanism of these herbs at molecular level by examining the effects on various injurious factors. Both Saireito and Onpi-to are effective agents for delaying the progression of CKD.