肾综合征出血热患者血、尿肽结合羟脯氨酸含量的临床评价

Clinical significance of the peptide-bound hydroxyproline in serum and urine of patients with hemorrhagical fever withrenal syndrome

用紫外分光光度法测定了15例正常人和37例肾综合征出血热（HFRS）患者在不同病期血、尿肽结合羟脯氨酸（PHP）的改变。37例HFRS患者血PHP均高于正常人（均P＜0．01）；尿PNP排出量（μmol／24h）在发热期、恢复期接近正常人（均P＞0．05），在低血压休克期、少尿期均低于正常人（P＜0．001），多尿期高于正常人（P＜0．05）。低血压休克期和少尿期血PHP与血BUN、Scr呈正相关（P＜0．001），尿PHP与血BUN、Scr呈负相关（P＜0．001）。结果提示血PHP、尿PHP可能是判断肾功能状态的新的敏感指标。

The peptide-bound hydroxyproline (PHP) in serum and urine of 15 normal subjects and 37 cases of he-morrhagical fever with renal syndrome (HFRS) was determined with the ultraviolet spectrophotometry. The resultsshowedthat the mean PHP in serum of the 37 patients with HFRS is higher than that of the nomal subjects (P<0. 001 ),the quantity of urjnary PHP in 24 hours in febrile and convalescent stages was close to that of the normal per-sons P>0.05, in hypotensive and oliguric stages, lower than that of the normal controls (P<0. 001 ); and in diureticstage, higher than that of the normal subjects (P<0. 05). The concentration of PHP in serum in hypotensive and olig-uric stages were positively correlated to BUN and Scr in serum respectively while the PHP urine excretion was negativelycorrelated to BUN and Scr in serum respectively. These results suggested that the test of concentration of the PHP inserum and the PHP urine excretion might help to ascertain the condition of renal function.