系统性红斑狼疮妊娠合并妊高征的前瞻性研究

The Prospective study of SLE with pregnancy induced hypertension

目的：探讨系统性红斑狼疮（SLE）对重度妊高征（PIH）发病影响及对母儿危害。方法：80例SLE妊娠的临床资料前瞻性研究。结果：活动期SLE肾炎孕妇合并重度PIH的发生率10／22例（45％）。稳定期SLE肾炎1／12例（83％），其它皮肤型SLE2／46例（4．3％）。文献报告[1]活动期SLE肾炎与重度PIH很难鉴别且母死亡率可高达50％～80％，胎儿死亡率12．9％～45．5％[1，5]。结论：两者诊断正确时，分别给予增加激素控制活动及硫酸镁控制病情，适时干预性早产，羊膜腔内注射地塞米松，可使孕妇转危为安及提高早产儿成活率。本文孕妇80例及新生儿81例（双胎1例）均存活。

Objective: To study the morbility influence, impairment of maternal fetal of SLE to severe PIH. Meth-ods:Prospective analysis of clinical materials of 80 cases systemic lupus erythematous accompained with pregnancy in-duced hypertension. Results:Activity SLE with nephritis in pregnancy complicated with severe PIH. The morbidity ratewere 10/22 cases (45% ). Stabled SLE nephritis 1/12 cases (8. 3% ). Other skin typed SLE 2/46 cases (4. 3% ). Ac-cording to references report[1],Activity SLB with nephritis is difficult to differentiate from severe PIH and maternal mor-tality rate up to 50~80%. Fetal mortality rate reads as 12. 9~ 45. 5 %[1.5]. Diagnosis proper of maternal fetal each in-creaseded steroids administration to control the activity and magnesium sulfate to control the symptom of disease. Intraaminotic injection of dexamethasone to interfere prematurity can save the mother from risk to safety and increase the su-ruival rate of prematurity fetal. We reported on the survived 80 cases of mother and 81 cases of new born fetal (involved1 case of twin).