原发性肝癌组织中幽门螺旋杆菌感染的研究

HELICOBACTER PYLORI INFECTION IN PRIMARY HEPATIC CARCINOMA

随机选取哈尔滨医科大学附属肿瘤医院病理科1998—2006年的肝病患者的石蜡包埋组织62例,其中原发性肝癌(primary hepatic carcinoma,PHC)33例、对照组肝硬化或癌旁组织14例、肝脏良性肿瘤(血管瘤、肝囊肿)15例.采用S-P免疫组化技术,对PHC组织中幽门螺旋杆菌(helicobacter pylori,HP)的感染情况进行了研究,并了解两者之间的相关性,结果显示33例PHC标本中有14例观察到HP的存在,而对照组肝硬化和肝脏良性肿瘤组织中未观察到HP的存在.证明PHC组织中存在HP感染,两者之间存在一定的相关性,进一步证实HP感染很可能是PHC的一个重要致病因素,为PHC的研究提供了参考依据.

Excised diseased liver samples wax embeded at The Tumour Hospital, Harbin Medical University from 1998 -2006 were examined. Samples from 62 patients were examined, primary hepatocarcinoma 33 samples, cancer--surrounding tissues and liver cirrhosis 14 samples, benign liver tumor （angioma, liver cyst） 15 samples. S-P immunohistochemical staining revealed that of the 33 example primary hepatocarcinoma specimens H. pilori was observed in 14, samples in all other groups were negative. Therefore a likely correlation was noted between H. pilori infection and primary hepatocarcinoma occurrence.