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LRH-1在女性生殖和乳腺癌中的研究进展 被引量：6

LRH-1 IN FEMALE REPRODUCTION AND BREAST CANCER
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摘要 肝受体类似物-1(liver receptor homolog-1,LRH-1;NR5A2)是转录因子家族中的新成员,表达于肝、肠、胰腺和卵巢,尤其在卵巢高表达,参与胚胎发育的调节.近年来发现LRH-1还表达于人类乳腺中未分化脂肪组织的间质层,可能参与前脂细胞功能调节或脂肪细胞分化.因此对LRH-1的研究有助于揭示LRH-1与人类生殖及疾病的关系,为疾病的早期诊断和有效治疗提供了新靶点. Liver receptor homolog-1 （LRH-1; NR5A2） is a member of Ftz-F1 subfamily of nuclear receptors. LRH-1 is expressed in liver, intestine, exocrine pancreas and ovary. High expression of LRH-1 in ovary and undifferentiated mesenchyma in human breast adipose tissue may regulate pre-adipocyte function or adipocyte differentiation. LRH-1 could provide a new target for the effective treatment and early diagnosis of gynaecological and obstetrical disorders.
作者 赵红 丁晓萍
机构地区 辽宁医学院妇产科教研室 第二炮兵总医院妇产科
出处 《北京师范大学学报（自然科学版）》 CAS CSCD 北大核心 2008年第3期323-327,共5页 Journal of Beijing Normal University(Natural Science)
关键词 肝受体类似物-1 类固醇生成因子1 孤儿核受体 干细胞多能性调节基因 芳香化酶(P450arom) 卵 巢 胚胎发育 乳腺癌 liver receptor homolog-1 steroidogenic factor-l orphan nuclear receptor Oct4 aromase（P450arom） ovary embryonic development breast cancer
分类号 S858.292 [农业科学—临床兽医学] X503.1 [环境科学与工程—环境工程]
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参考文献22

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二级参考文献13

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同被引文献59

  • 1温海霞,刘国艺,倪江.孤儿核受体肝受体同系物-1以及与雌激素相互调节作用[J].生殖医学杂志,2007,16(2):124-128. 被引量：10
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引证文献6

二级引证文献10

北京师范大学学报（自然科学版）
2008年 第3期

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