利培酮与再普乐治疗酒精所致精神障碍的对照研究

A comparative study of risperidone and olanzapine in the treatment of mental disorders due to use of alcohol

目的:比较利培酮与再普乐对酒精所致精神障碍患者的疗效和不良反应。方法:将70例酒精所致精神障碍患者随机分为利培酮组(37例)和再普乐组(33例),疗程6周,于治疗前及治疗后1、2、4、6周采用阳性症状和阴性症状量表(PANSS)、治疗时出现的症状量表(TESS)评定疗效与不良反应。结果:利培酮与再普乐对酒精所致精神障碍患者的治疗均有明显疗效,统计学上无显著性差异(P>0.05),利培酮组锥体外系不良反应明显高于再普乐组(P<0.05)。结论:利培酮与再普乐治疗酒精所致精神障碍患者安全有效。

Objective： To compare the efficacy and side effects ofrisperidone and olanzapine in the treatment of mental disorders due to use of alcohol. Methods： 70 mental disorders due to use of alcohol were randomly divided into risperidone group （n=37） and olanzapine group （n= 33）. They were treated for 6 weeks. The clinical efficacy and side effects were evaluated with PANSS and TESS before treatment and 1,2,4,6 weeks after treatment. Resuits： There were significant efficacy in risperidone gronp and olanzapine group, there were no significant difference in statistics （P〉0.05）. Incidence of extra-pyramidal symptoms in risperidone group were significantly higher than those in olanzapine group （P〈0.05）. Conclusions： Risperidone and olanzapine showed efficacy and safety in the treatment of mental disorders due to use of alcohol.