自体LAK细胞回输治疗前后慢乙肝患者门静脉血流动力学的研究

CHANGES IN PORTAL HEMODYNAMICS IN PATIENTS WITH CHRONIC HEPATITIS B AFTER LAK CELL TREATMENT

研究自体ＬＡＫ细胞回输治疗前后慢乙肝患者门静脉血流动力学。方法应用超声多普勒系统测量１８例经自体ＬＡＫ细胞回输治疗的慢乙肝患者治疗前后门静脉血流动力学参数。结果治疗前门静脉截面积与对照组比较明显增宽（Ｐ＜０．０１），治疗后仍宽于对照组（Ｐ＜０．０１），但比治疗前变窄（Ｐ＜０．０５）。治疗前后血流速度与对照组比较均无显著性差异（Ｐ＞０．０５）。治疗前门静脉血流量明显多于对照组（Ｐ＜０．０１），治疗后与治疗前比较明显减少（Ｐ＜０．０１），与对照组比较无差异（Ｐ＞０．０５）。结论自体ＬＡＫ细胞回输治疗可以改善慢乙肝患者门静脉血流动力学状态。

Objective To study the changes in portal hemodynamics in the patients with chronic hepatitis B (CHB) treated with LAK cells.Methods The changes of portal hemodynamics were measured by using ultrasonic Doppler system in 18 patients with CHB before and after treatment with self LAK cell infusion.Results The results showed that the crossectional area of portal vein in the treated patients was significantly reduced (P<0.05),although it was still larger than the control (P<0.01).There was no significant difference in the velocity of portal venous blood flow between the patients and controls,before or after treatment (P>0.05). The quantity of portal venous blood flow, greatly increased in the patients (P<0.01),was markedly lowered after treatment (P<0.01),similar to that of the control (P>0.05).Comclusion These results suggest that the therapy of self LAK cell infusion can improve the portal hemodynamics in CHB patients.