胃肠外营养与地塞米松协同调节肺癌细胞周期的初步探讨

Cooperative Regulation of Parenteral Nutrition and Dexamethson on the Cell Cycle in Lung Cancer

采用胃肠外营养（PN）、地塞米松（DM）及PN＋DM对36只人肺腺癌裸鼠模型LAX－83肿瘤细胞中中期细胞百分率（S％）的影响，PN组予12．54kJ／kg-1·d-1＋氮量0．2g／kg－1·d-1，DM组予20μg／d，对照组予生理盐水，分2次早晚腹腔注射，用FCM测定S％，结果，24h，PN＋DM组的S％增加最大，显著高于对照组，提示PN＋DM的联合作用。24h后对S％增加有协同作用。

In order to dermine the effect of peenteral nutrition (PN), dexamethson (DM) and theircombination(PN+DM) on lung cancer. Thirty six nude mice bearing human adenocarcinoma of thelung cameinto ewperiments. The alterations of DNA synthesis phase in tumor cells were detected withFCM method. the 24hr of administration, percentage of S phase cells (S%) were53. 4± 10. 2,46. 5± 9. 1,and 59. 8±8. 0 for PN,DM and PN+DM respectively. In the control group it was 44. 7± 8. 1. After 48hr,S% in the above three groups were 36. 4± 4. 8' 39. 9± 6. 6,and 46, 6± 6. 9,respectively. In the control group it was 44. 4±8. 8. The results showed that S% in PN+DM groupat 24hr was increased significantly(P<0. 05) compeing with thase in the control group and suggestedthat the PN+DM combination at 24hr post-administration might have synergistic effect on the ratioof tumor cells at S phase,This alterated cytokinetics might influence the chemosensitivity of tumorcells to cycle-specific agents.