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调节性T细胞在血液系统恶性肿瘤中的研究进展 被引量：3

Research progress of CD^＋4CD^＋25 Foxp3 Treg cells in the hematological malignancies
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摘要 胸腺产生的CD^＋4CD^＋25调节性T细胞（Treg细胞）被认为在控制自身免疫、防止移植物排斥反应、抑制抗感染自身免疫以及抑制异基因免疫反应中发挥重要作用。最近有报道此类细胞有抑制机体抗肿瘤的作用。Foxp3是Treg细胞最具特异性的蛋白分子标志物。阐述了血液系统恶性肿瘤患者CD^＋4CD^＋25去Foxp3 Treg的表达以及其对免疫治疗的潜在作用。 Thymus derived CD^＋4CD^＋25 regulatory T cells （Treg） are thought to be specific T cells that play an important role in controlling autoimmunity, preventing transplant rejection, restraining anti-infectious immune response, suppressing allogeneic immune respons. More recently, these cells are reported to have the ability of suppressing antitumor immune response. Foxp3 are the most specific protein of Treg. In this review, we will discuss the expression of CD^＋4CD^＋25 Foxp3 Treg in patients with hematological malignancies and its implication for immunotherapy.
作者 邵亮(综述) 张铀(审校)
机构地区 昆明医学院第二附属医院血液科
出处 《白血病．淋巴瘤》 CAS 2008年第3期237-240,共4页 Journal of Leukemia & Lymphoma
关键词 血液肿瘤 T淋巴细胞 调节性 细胞毒性 免疫 血液和免疫系统 Hematologic neoplasms T-lymphocytes, regulatory Gytotoxicity, immunologic Hemic and immune systems
分类号 R730.51 [医药卫生—肿瘤]
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参考文献31

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二级参考文献17

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白血病．淋巴瘤
2008年 第3期

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