迟发性运动障碍与抗精神病药物治疗关系的研究

Study of relationship between tardive dyskinesia and antipsychotics.

目的观察迟发性运动障的发生与长期应用抗精神病药物的关系。方法选取北京回龙观医院长期住院的患者,符合CCMD-3精神分裂症的诊断标准,抗精神病药剂量恒定维持治疗6个月。排除器质性疾病及其它神经精神疾患。先用Simpson迟发性运动专业量表进行全院患者筛选,最终选出合乎要求病例109例,再用AIMS量表评定,依据患者用药情况分为三组,典型抗精神病药组(包括氯丙嗪、奋乃静、氟哌啶醇、安棕酯)、氯氮平组、利培酮组,使用SPSS10.0,采用独立样本t检验、单因素方差分析,分析三组药物与TD的相关性。结果利培酮组的AIMS总分显著低于典型抗精神病药组(p=0.032),与氯氮平组无显著差异(P=0.275)。结论利培酮组,氯氮平组致TD症状的严重程度偏低,或对TD症状有一定抑制或治疗作用。

Objective To observe the relationship between the occurrence of tardive dyskinesia（TD） and long-term application of treatments with antipsychotics. Methods Lon-term in-patients in Beijing Huilongguan Hospital were selected according with the diagnosis criteria of CCMD-3 for schizophrenia, whose dose of antip- sychotics had not been changed for 6 months. Organic diseases,other neuropathies and mental diseases were excluded. At first,all patients in the hospital were assessed with Simpson Special Scale for TD and 109 patients were selected,then these patients were assessed with AIMS. Patients were divided into three groups： classical antipsychotic group （including chlorpromazine, perphenazine, haloperidol, pipotiazine palmitate ）, clozapine group and risperidone group. Independent sampler t-test and one-factor analysis of variance were used in SPSS. Results The total score of AIMS in risperidone group was significantly lower than that of classical group （P= 0. 032）, and had no difference with clozapine group （P=0. 275）. Conclusion The severity degree of TD caused by clozapine and risperidone is lower, and the two drugs could restrain or treat TD to some extent.