摘要
目的比较奥氮平合并小剂量丙戊酸镁缓释片与单用奥氮平治疗急性期精神分裂症的疗效。方法40例急性期精神分裂症患者随机分为合并组与单用组治疗,疗程2周,分别于治疗前、第1周末、第2周末采用PANSS量表评分并分析。结果第1周末合并组与单用组之间的疗效差异有统计学意义(χ2=8.37,Ρ=0.02),第2周末两组之间的差异无统计学意义(χ2=4.78,Ρ=0.063);PANSS量表评分均数:合并组在第1、2周末均与治疗前比较有统计学意义(Ρ<0.05),而单用组在第2周末与治疗前比较有统计学意义(Ρ<0.05)。结论奥氮平合并小剂量丙戊酸镁缓释片能更快、更有效地控制急性期精神分裂症的兴奋激越症状。
Objective To compare the efficacy of olanzapine with small-dose sustained-release tablets of magnesium valproate and olanzapine only in treatment of patients with acute phrase of schizophrenia. Methods A total of 40 patients with acute phrase of schizophrenia were randomly divided into two groups olazapine group and olanzapine with magnesion valproate group, for treatment of two weeks. PANSS was assessed before treatment, 1st weekend and 2nd weekend. Results At the first weekend,there had significant difference on efficacy between two groups(Χ^2=8.37, P= 0.02) and at the second weekend,the difference was not found (Χ^2= 4. 78, p = 0.063 ). The scores of PANSS in combining group of the first and the second weekend were significantly lower than those before treatment (P〈0.05), but in the single group the significant difference was only found between the second weekend before treatment (p〈 0.05). Conclusion Olanzapine with small-dose sus- tained-release tablets of magnesium valproate should take into effective fast for controlling the excitement symptoms in the acute phrase of schizophrenia.
出处
《精神医学杂志》
2008年第3期178-179,共2页
Journal of Psychiatry
关键词
奥氮平
丙戊酸镁缓释片
精神分裂症
Olanzapine Sustained-release tablet of magnesium valproate Schizophrenia