期刊文献+

奥氮平合并小剂量丙戊酸镁缓释片治疗急性期精神分裂症的对照研究 被引量:16

A comparative study of olanzapine with small-dose sustained-release tablets of magnesium valproate in treatment of acute phrase of schizophrenia.
下载PDF
导出
摘要 目的比较奥氮平合并小剂量丙戊酸镁缓释片与单用奥氮平治疗急性期精神分裂症的疗效。方法40例急性期精神分裂症患者随机分为合并组与单用组治疗,疗程2周,分别于治疗前、第1周末、第2周末采用PANSS量表评分并分析。结果第1周末合并组与单用组之间的疗效差异有统计学意义(χ2=8.37,Ρ=0.02),第2周末两组之间的差异无统计学意义(χ2=4.78,Ρ=0.063);PANSS量表评分均数:合并组在第1、2周末均与治疗前比较有统计学意义(Ρ<0.05),而单用组在第2周末与治疗前比较有统计学意义(Ρ<0.05)。结论奥氮平合并小剂量丙戊酸镁缓释片能更快、更有效地控制急性期精神分裂症的兴奋激越症状。 Objective To compare the efficacy of olanzapine with small-dose sustained-release tablets of magnesium valproate and olanzapine only in treatment of patients with acute phrase of schizophrenia. Methods A total of 40 patients with acute phrase of schizophrenia were randomly divided into two groups olazapine group and olanzapine with magnesion valproate group, for treatment of two weeks. PANSS was assessed before treatment, 1st weekend and 2nd weekend. Results At the first weekend,there had significant difference on efficacy between two groups(Χ^2=8.37, P= 0.02) and at the second weekend,the difference was not found (Χ^2= 4. 78, p = 0.063 ). The scores of PANSS in combining group of the first and the second weekend were significantly lower than those before treatment (P〈0.05), but in the single group the significant difference was only found between the second weekend before treatment (p〈 0.05). Conclusion Olanzapine with small-dose sus- tained-release tablets of magnesium valproate should take into effective fast for controlling the excitement symptoms in the acute phrase of schizophrenia.
出处 《精神医学杂志》 2008年第3期178-179,共2页 Journal of Psychiatry
关键词 奥氮平 丙戊酸镁缓释片 精神分裂症 Olanzapine Sustained-release tablet of magnesium valproate Schizophrenia
  • 相关文献

参考文献7

  • 1[1]Hughes DH,Kleespies PM.Treating aggression in psychiatric emergency service[J].Clin Psychiatry,2003,64 Suppl 4:10-15
  • 2[2]Allen MH,Cumier GW,Hughes DH,et al.The expert consensus guideline series,treatment of behavioral emergencies[J].Postgrad Med,2001,1-88
  • 3[3]Van Putten T,Marder SR,Mintz J.A controlled dose comparison of haloperidol in newly admitted schizophrenia patients[J].Arch Gen Psychiatry,1990,47:754
  • 4高桂林,陈莉.奥氮平治疗首发精神分裂症的疗效分析[J].上海精神医学,2003,15(1):33-34. 被引量:29
  • 5[5]Tran PV,Dellva MA,Tollefson GD,et al.Oral olanzapine versus oral haloperidol in the mainteance treatmeat of schizophrenia and related psychoses[J].Br J Psychiatry,1998,172:499-505
  • 6杨献红,黄继忠,严和骎,江开达,陆峥,盛尤荣,熊祥玉,冯明德,姚维菊,吴敏.奥氮平治疗精神分裂症70例临床分析[J].上海精神医学,2002,14(2):94-96. 被引量:26
  • 7[7]T ran PV,Hamilton SH,Kuntz AJ,et al.Double-blind comparison of olanzapine versus risperidone in the treatment of schizophrenia and other psychotic disorders[J].J Clin Psychophamacol,1997,17(5):407-418

二级参考文献14

  • 1王长虹,冯砚国,王来海.奥氮平与氯氮平治疗精神分裂症的双盲对照研究[J].上海精神医学,2002,14(3):143-145. 被引量:13
  • 2[1]沈渔村主编.精神病学,第二版.北京:人民卫生出版社,1992,238~239
  • 3[6]Tollefson GD,Sanger TM. Negative symptoms: a path analytic approach to a doubled-blind,placed and haloperidol Controlled clinical trial with olanzapine. Am J Psychiatry,1997,154(5):466~474
  • 4Beasley CM Jr, Tollefson GD, Tran PV. Efficacy of olanzapine: an overview of pivotal of clinical trials. J Clin Psychiatry, 1997, 58(Suppl 10) : 7
  • 5Beasley CM Jr, Tollefson GD, Tran PV. Safety of olanzapine. J Clin Psychiatry, 1997, 58 (Suppl 10) : 13
  • 6Tollefson GD, Beasley CM Jr, Tran PV, et al. Olanzapine versus haloperidol in the trearment of schizophrenia and scbizoaffective and schizophreniform disorders: results of an international collaborative trial. Am J Psychiatry, 1997, 154 : 457
  • 7Tollefson GD, Beasley CM Jr, Tamura RN, et al. Blind, controlled, long-term study of the comparative incidence of treatmentemergent tardive dyskinesia with olanzapine or haloperidol. Am J Psychiatry, 1997, 154: 1248
  • 8Tran PV, Dellva MA, Tollefson GD, et al. Extrapyramidal symptoms and tolerability of olanzapine versus haloperidol in the scute treatment of schizophrenia. J Clin Psychiatry, 1997, 58 : 205
  • 9舒良,刘平.新型非典型抗精神病药奥氮平[J].中华精神科杂志,1999,32(2):123-123. 被引量:49
  • 10舒良,刘平,周沫,王希林,张鸿燕,郭俊花,周方,侯也之.奥氮平治疗精神分裂症的开放性临床验证[J].中华精神科杂志,1999,32(4):223-225. 被引量:98

共引文献52

同被引文献101

引证文献16

二级引证文献47

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部