期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脊髓损伤后促红细胞生成素防御保护性机制研究进展 被引量：2

原文传递
导出
摘要 随交通运输的高速化、体育运动的极限化及频发的暴力意外伤害，脊髓损伤（SCI）的发生呈现：高致残率、低死亡率、治疗耗费高等特点，并业已成为全球性医疗棘手问题。促红细胞生成素（EPO）是由肾脏分泌用以调节红细胞生成的糖蛋白激素之一，
作者 巩腾 冯世庆 王沛
机构地区 天津医科大学总医院骨外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2008年第6期813-814,共2页 Chinese Journal of Experimental Surgery
基金 国家自然科学基金资助项目（30271313） 天津市科委自然科学基金组资助项目（043609011）
关键词 促红细胞生成素 脊髓损伤 保护性 防御 糖蛋白激素 交通运输 意外伤害 体育运动
分类号 R651.2 [医药卫生—外科学]
  • 相关文献

参考文献12

  • 1Grasso G, Sfaeteria A, Meli F, et al. The role of erythropoietin in neuroproteetion: therapeutic perspectives. Drug News Perspeet, 2007,20 : 315 -320.
  • 2Thiemermann C. Beneficial effects of erythropoietin in preclinical models of shock and organ failure. Crit Care, 2007, 11 : 132.
  • 3薛文,孙正义,张海鸿,刘京升,康学文,孟涛.低氧诱导因子-1α在大鼠脊髓缺血再灌注损伤中的表达[J].中华实验外科杂志,2004,21(11):1346-1348. 被引量：9
  • 4Wang F, Zhang R, Beischlag TV, et al. Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. J Biol Chem, 2004, 279:46733-46741.
  • 5谢金元,郑启新,郭晓东,吴永超,王金先,郭伟韬.重组人红细胞生成素对大鼠背根神经节细胞钙通道的调节作用[J].中华实验外科杂志,2007,24(6):727-730. 被引量：7
  • 6Okutan O, Solaroglu I, Beskonakli E, et al. Recombinant human erythropoietin decreases myeloperoxidase and Caspase-3 aetlvity and improves early functional results after spinal eord injury in rats. J Clin Neurosci ,2007,14:364-368.
  • 7Brines M, Grasso G, Fiordaliso F, et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Proc Natl Acad Sci USA,2004,101 : 14907-14912.
  • 8Grasso G, Sfacteria A,Erbayraktar S,et al. Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative. J Neurosurg Spine,2006,4:310-318
  • 9Sonmez A, Kabakei B, Vardar E, et al. Erythropoietin attenuates neuronal injury and potentiates the expression of pCREB in anterior horn after transient spinal cord ischemia in rats. Surg Neurol, 2007, 68: 297-303.
  • 10Loblaw DA,Holden L,Xenocostas A,et al. Functional and pharmacokinetic outcomes after a single intravenous infusion of recombinant human erythropoietin in patients with malignant extradural spinal cord compression. Clin Oncol (R Coll Radiol ), 2007,19:63-70.

二级参考文献34

  • 1Le QT,Giaccia AJ.HIF-1α,a gender independent transcription factor.Clin Cancer Res,2003,9:2391-2393.
  • 2Semenza GL.HIF-1α,O2 and the 3 PHDs.How animal cells signal hypoxia to the nucleus.Cell,2001,107:1-3.
  • 3Scharte M,Han X,Bertges DJ,et al.Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes.Am J Physiol Gastrointest Liver Physiol,2003,284:373-384.
  • 4Treins C,Giorgtti-Peraldi S,Murdaca J,et al.Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.J Biol Chem,2002,277:27975-27981.
  • 5Pirel J,Mollel D,Raes M,et al.Is HIF-1alpha a pro-or an anti-apoptotic protein?Biochem Pharmacol,2002,64:889.
  • 6Liu LX,Lu H,Luo Y,et al.Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1.Biochem Biophys Res Immun,2002,291:908-914.
  • 7Jones NM,Bergeron M.Hypoxic preconditiong induces changes in hif-1 target genes in neonatal rat brain J.Jcered Blood Flow Metab,2001,21:1105-1114.
  • 8Ashley RA, Dubuque SH, Dvorak B, et al. Erythropoietin stimulates vasculogenesis in neonatal rat mesenteric microvascular endothelial cells. Pediatr Res ,2002,51:472-478
  • 9Chikuma M, Masuda S, Kobayashi T, et al. Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus. Am J Physiol Endocfinol Metab ,2000,279:1242-1248.
  • 10Dame C, Bartmann P, Wolber E, et al. Erythropoietin gene expression in different areas of the developing human central nervous system. Brain Res Dev Brain Res,2000,125:69-74.

共引文献14

同被引文献9

  • 1ZHANG S H , DANCKERT J . Development of hydro-mechanical deep drawing [ J ]. J Mater Process Technol,1998, 83: 14-25.
  • 2KLEINER M , GARTZKE A , KOLLECK R , et al . Finite element simulation for high pressure sheet metal forming ( HBU Process ) and tool constr-uction [ A ]. Advanced Technology of Plasticity[C]. [s l]:[ s n], 1996. 975 - 983.
  • 3NOVOTNY S , HEIN P . Hydroforming of sheet metal pairs from aluminum alloys[ A]. Proceedings of the SheMet' 99[C].[s l]:[s n], 1999, 9:591 -598.
  • 4PALUMBO G, TRICARICO L , PINTO S . Single sheet hydroforming in the realization of complex parts[J]. International Conference on Hydroforming, Fellbach -Germany,2003, 3: 499-520.
  • 5KIM T J , YANG D Y , HANS S . Improvement of formability in hydroforming process of sheet metal pairs by multy-stage forming[ A]. Tube Hydroforming 2003[ C]. Aich:[s n] ,2003.
  • 6ZHANGS H , XU Y , ZHOU LX , et al. Comput-er simulation on sheet hydroforming with a movable female die [A]. Proceedings of NUMISHEET' 2002' [ C]. Jeju: [ sn] ,2002. 391 - 397.
  • 7胡杨,郑启新.促红细胞生成素对急性脊髓损伤后氧自由基和Caspase-3表达变化的干预作用[J].中华实验外科杂志,2008,25(11):1526-1526. 被引量：3
  • 8胡杨,郑启新,郭晓东,刘建湘,刘勇,刘国辉,廉凯.促红细胞生成素治疗急性脊髓损伤[J].中华实验外科杂志,2009,26(11):1535-1536. 被引量：3
  • 9熊敏,陈森,曾云,刘志刚,余化龙,李锋.促红细胞生成素动员骨髓间充质干细胞治疗脊髓损伤[J].中华实验外科杂志,2011,28(4):618-620. 被引量：18

引证文献2

二级引证文献4

中华实验外科杂志
2008年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部