甘糖酯对冠心病伴高脂血症患者血脂、血清氧化修饰低密度脂蛋白、C-反应蛋白的影响

Effects of mannose ester on blood lipids,serum oxidized low density lipoprotein,C-reactive protein in patients with coronary heart disease complicated with hyperlipidemia

目的探讨甘糖酯的调脂作用及其对冠心病患者血脂、血清氧化修饰低密度脂蛋白、C-反应蛋白的影响。方法分别给予76例患高脂血症的冠心病患者甘糖酯(0.1g/次,每天3次)口服连续2个月,然后测定患者的血脂、血清氧化修饰低密度脂蛋白、C-反应蛋白的水平。结果甘糖酯应用1个月后即可有效降低TC、LDL-C水平,2个月后疗效进一步提高,并能降低TG、升高HDL-C。患者血清氧化修饰低密度脂蛋白、C-反应蛋白的水平也显著地降低。结论甘糖酯具有良好的调脂效果,能降低患者血清氧化修饰低密度脂蛋白、C-反应蛋白,并具有抗氧化和保护血管内皮功能、抑制斑块内炎症的作用,有利于冠心病患者预后的改善。

Objective To study the lipid regulatory effects of mannose ester and its effects on serum oxidized low density lipoprotein（OX-LDL）,C-reactive protein（CRP） in patiends with coronary heart disease （CHD）complicated with hyperlipidemia. Methods Seventy-six CHD patients with hyperlipidemia were treated with mannose ester at a dose of 0. lg orally, three times a day for 2 successive months. Levels of blood lipids,OX-LDL, CRP at the time of entry,first month, second month of the therapeutic course were observed. Results Mannose ester could reduce the serum levels of total cholesterol, LDL-C 1 month after medication and the effect was further elevated after 2 months. Meanwhile its effects in lowering triglycerides and increasing high density lipoprotein were observed after 2 months administration. Mannose ester could also significantly lower the serum OX-LDL , CRP after 2 months administration. Conclusion Mannose ester has good regulatory effect on blood lipids,and decreases OX-LDL, CRP. Mannose ester can protect vascular endothelial cells and inhibit the development of inflammation in coronary plaque. Therefore, it can improve the prognosis of CHD patients.