胰岛素样生长因子-1及其受体与前列腺癌

Insulin-like growth factor-1,insulin-like growth factor-1 receptor and prostate cancer

胰岛素样生长因子-1作为胰岛素样生长因子家族中的重要组成部分,可以通过与胰岛素样生长因子-1受体结合并激活其下游的信号传导通路,发挥广泛的生物学作用,在前列腺癌的发生、发展及转移中亦具有重要的作用。随着研究的深入,针对胰岛素样生长因子-1受体信号通路的特异性靶向药物应运而生,其中,应用最多的是IGF-ⅠR单克隆抗体,在恶性肿瘤包括前列腺癌的治疗中具有广泛的应用价值。

Insulin - like growth factor - Ⅰ （ IGF - Ⅰ） is an important member of IGF family. It plays an important role in the carcinogenesis and development of prostate cancer by activating insulin - like growth factor 1 receptor and its downstream molecules. Recently, a multitude of agents are produced to block the activation of IGF - Ⅰ R and downstream signaling pathway, and several anti - IGF - Ⅰ R monoclonal antibodies have been reported very successful in the treatment of prostate cancer in in vitro and in vivo studies.