螺 1,3-嗪的合成及环链互变异构现象

SYNTHESIS OF SPRIO 1,3 OXAZINES ANDRING CHAIN TAUTOMERISM

螺唑衍生物，３，８－二取代－１－氧杂－２，８－二氮杂螺［４，５］－２－癸烯，经加氢开环成γ－氨基醇４，４与丙酮及苯甲醛等化合物缩合，生成了由环式化合物螺１，３－嗪及链式化合物西佛碱组成的互变异构体．

Spiro 1,3 oxazole derivatives, 3,8 disubstituted 1 oxa 2.8 diazaspiro[4,5] 2 decene, were cleaved by hydrogenolysis to γ amino alcohols 4. Through condensation of γ amino alcohols 4 with aceton or benzaldehyde, tautomeride of 1,3 oxazines and open chain schiff bases were obtained.