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外源基因在转基因蚊虫中表达的研究进展 被引量：1

HETEROLOGOUS EXPRESSION IN TRANSGENIC MOSQUITOES
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摘要 利用转基因技术对蚊虫进行遗传修饰使其密度下降或降低其传播疾病的能力是控制蚊媒传染病的一个新策略。其核心问题是外源基因在转基因蚊虫体内的表达。本文从转基因蚊虫的表达载体、外源基因表达特性及效应、转基因蚊虫研究存在的问题及发展前景等方面对该领域的研究进展进行了综述。 Mosquitoes are vectors of serious human infectious diseases, such as malaria, dengue and yellow fever. Genetically modification of mosquitoes has been proposed as a new strategy to control mosquito-borne diseases. The central event in transgenic mosquitoes is the heterologous expression of exo-genes. This review addresses mainly the relevant progress in the f/eld of heterologous expression in transgenic mosquitoes such as transgenic mosquitoes expression vectors, heterologus expression characteristics and effect in transgenic mosquitoes and some points need to be attended in the future study.
作者 丁雪冰 陈晓光
机构地区 南方医科大学公共卫生与热带医学学院病原生物学系
出处 《寄生虫与医学昆虫学报》 CAS 2008年第2期108-114,共7页 Acta Parasitologica et Medica Entomologica Sinica
基金 国家自然科学基金资助项目(No.30271162)
关键词 外源基因 转基因蚊虫 转基因体系 表达特性 表达效应 Heterologous expression Transgenic mosquitoes Transgenic systems Expression characteristics Effect of the expression
分类号 R384 [医药卫生—医学寄生虫学]
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参考文献25

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同被引文献45

  • 1公茂庆,顾燕,马磊,李秀兰,胡小邦,孙艳,孙立新,孙静,钱瑾,朱昌亮.外源性双链RNA在蚊虫细胞中介导的基因沉默(英文)[J].中国寄生虫病防治杂志,2004,17(5):261-263. 被引量：1
  • 2郑学礼,陈晓光,王春梅.转基因蚊研究进展[J].中国寄生虫病防治杂志,2005,18(4):307-310. 被引量：2
  • 3李洁,张应阔,钱万红.蚊虫控制技术研究进展[J].昆虫知识,1997,34(2):109-112. 被引量：6
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  • 6Lines JD, Curtis CF. Genetic sexing systems in Anopheles ara- biertsis Patton ( Diptera: Culicidae) [ J]. J Econ Entomol, 1985, 78(4) :848-851.
  • 7Shetty NJ. Genetic sexing system for the preferential elimination of females in Culex quinquefasciatus[ J]. J Am Mosq Control As- soc, 1987,3(1) : 84-86.
  • 8Hood-Nowotny R,Mayr L,Knols BG. Use of carbon-13 as a pop- ulation marker for Anopheles arabiensis in a sterile insect teeh-nique (SIT) context[J]. Malar J,2006,5:6. doi: 10. 1186/ 1475 -2875-5-6.
  • 9Catteruccia F, Benton JP, Crisanti A. An Anopheles transgenic sexing strain for vector control[ J]. Nat Biotechno1,2005,23 ( 11 ) : 1414-1417.
  • 10Catteruccia F, Crisanti A, Wimmer EA. Transgenic technologies to induce sterility[ J]. Malar J, 2009,8 ( Suppl 2 ) :S7. doi : 10. 1186/1475 -2875 -8-S2 -S7.

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寄生虫与医学昆虫学报
2008年 第2期

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