滋阴养血方对衰老血虚大鼠皮肤病治疗作用的实验研究

Experimental Study to the Curative Effects of Ziyin Yangxue Formula in Modeled Rats of Blood Deficiency Syndrome of Senile

目的:观察滋阴养血方对模型鼠的治疗作用,探讨其治疗老年皮肤瘙痒症的作用机理。方法:取22月龄大鼠48只,随机分为空白对照组、模型组、中药组3组,观察红细胞计数及鼠皮肤切片的皮脂腺数目及形态学变化。结果:用中药灌胃14d后,中药组大鼠红细胞和血红蛋白含量、皮脂腺数目及形态改善,接近对照组。与模型组差异显著,且有统计学意义(P<0.05)。结论:滋阴养血方对模型鼠养血作用较好,可增加皮脂腺数目,改善分泌,为治疗老年皮肤瘙痒症提供了实验依据。

Objective To observe curative effect of Ziyin Yangxue Formula on modeled rat, and explore its potential mechanism of curing senile pruritus. Methods 48 22-month-old rats were randomized into 3 groups： comparing group, modeled group, treated group. And were measured RBC, Hb, and morphologic changing of sebaceous glands. Results 14 days after given by Chinese herbs, the treated group showed significantly effect on elevating the amounts of RBC, Hb, on raising number of sebaceous glands, and on increasing sebaceous gland secretion in rats （P 〈 0.05）. Conclusion Ziyin Yangxue Formula is effective and it also could stimulate sebaceous gland secretion. It provides experimental results in treating senile pruritus.