HAART对HIV感染者／AIDS病人短期生活质量影响研究

Study on quality of life in AIDS patients receiving short-term highly active antiretroviral therapy(HAART)

目的探讨艾滋病病毒（HIV）感染者／艾滋病（AIDS）病人接受抗病毒治疗6个月时，生活质量有无变化。方法给予安徽省两地40名HIV感染者／AIDS病人高效抗逆转录病毒治疗（HAART），应用病历报告表的形式收集参加治疗病人的人口学信息、流行病学、临床及实验室检查信息，同时采用MOS-HIV量表，对病人治疗前和治疗6个月时生活质量进行调查，对相关数据进行统计分析。结果40名HIV感染者／AIDS病人平均年龄（42．2±8．8）岁（26～62岁），治疗前CD4平均为（197±41）个／μl（94～271），治疗6个月时体重平均增加（5．1±4．5）kg（t=7．24，P〈0．01），CD4平均增加（122±109）个/μl（t=7．07，P〈0．01）。采用MOS-HIV量表评定，病人躯体状况及精神状况在治疗后均有显著改善；维度分析显示，在健康感知、认知功能、疼痛、精神健康、精力与劳累、健康压力、生活状况、健康的变化方面，治疗前后的差异有显著的统计学意义（P〈0．01）。结论抗病毒治疗6个月时病人CD4细胞计数明显升高、体重增加、生活质量改善，躯体及精神状况均有所提高。

Objective To explore whether 6-month HAART can improve quality of life in AIDS patients.Method A total of 40 cases selected from 2 districts of Anhui province were treated with HAART, and their demographic, epidemiological, clinical and laboratory data were collected, MOS-HIV form was employed to evaluate patients＇ quality of life at baseline and after 6 month treatment, and relevont data were analyzed. Result The average age of these 40 patients was 42.2 ± 8.8 years（26 - 62 years）. The baseline CD4 count was 197 ± 410/μl（94 - 271）, while after 6-month antiretroviral therapy, the CD4 count and weight were elevated by 122 ± 109c/μl（ t = 7.07, P 〈 0.01 ） and 5.1 ± 4.5kg（ t = 7.24, P 〈 0.01）respectively.The evaluation of quality of life using MOS-HIV form indicated that patients＇physical and mental health conditions were both significantly improved, especially in terms of their general health status, pain perception, social functioning, psychology, energy and fatigue, distress, cognitive functioning, living conditions and transition of health. Conclusion The quality of life of AIDS patients receiving antiretroviral therapy for 6 months was significantly improved;the patients had elevated CD4 lymphocyte, gained weight and had better physical and mental health status.