羟基胆烷酸类衍生物的抗癌活性研究Ⅰ.3β,5α,6β-三羟基胆烷-24-酸及其衍生物的合成与体外抗癌活性

Study on the Antitumor Activity of Hydroxycholanic Acid Derivatives I.Synthesis and in vitro Antitumor Activity of 3β,5α,6β Trihydroxycholanic Acid and its Derivatives

报道３β，５α，６β三羟基胆烷２４酸及其衍生物的合成及对小鼠Ｌ１２１０白血病细胞的体外抗癌活性．实验表明３β，５α，６β三羟基胆烷２４酸，３β，５α，６β三羟基胆烷２４酸甲酯及３β。

This paper is to report synthesis of 3β,5α,6βtrihydroxycholanic acid,its derivatives and their leukamia L1210 cell growth inhibilion test in vitro.The result showed that 3β,5α,6βtrihydroxycholanic acid,methyl 3β,5α,6βtrihydroxycholanoate and methyl 3β,6βdiacetoxy5αhydroxy cholanoate possessed higher antitumor activity.