摘要
以对溴苯酚为原料,选择烯丙基保护酚羟基,制备了2(4烯丙氧苯基)乙醇(2).后者经成苷及脱乙酰基得到中间体(3),采用并改进氯化钯/氯化亚铜法脱除(3)中的烯丙基,合成了红景天苷(4).
2(4Allyloxypheny)ethanol(2) was prepared from pbromophenol.Salidroside(4) was synthesized from(2),via glucosidation and deprotective groups.The reagent of PdCl 2/CuCl was employed to deprotect allyl in (3) and the reactive conditions were improved.
出处
《中国药物化学杂志》
CAS
CSCD
1997年第4期256-257,273,共3页
Chinese Journal of Medicinal Chemistry