2-硫代四氢嘧啶-5-羧酸酯的合成及生物活性

Synthesis and Biological Activity of 2Thiotetrahydropyrimidine5Carboxylic Acid Esters

２硫代四氢嘧啶５羧酸酯的合成及生物活性谭日红１）（沈阳大学师范学院，沈阳１１００１５）孙佩霞（广州罗岗制药厂，广州５１０５３０）自从１９７７年硝基苯吡啶（ｎｉｆｅｄｉｐｉｎｅ，１）作为治疗高血压、心绞痛的药物投放市场以来，已有十几种二氢吡啶类钙...

Seven 2thiotetrahydropyrimidine5carboxylic acid esters were prepared by thiourea,benzaldehyde or mnitrobenzaldehyde and alkyl acetoacetates via the Biginelli reaction,were characterized by melting points,infrared spectra and proton NMR spectra,and exhibited some in vitro calcium antagonist activity.