摘要
通过高效液相色谱和薄层色谱分析阐明了利洛司酮中微量杂质的组成,由柱层析分离及化学合成方法获得两个主要杂质。
This paper elucidates the constitution of impurities in new antiprogestinlilopristone by HPLC and TLC analysis;Two main impurities were isolated by column chromatography and then synthesized in our lab.Their structures were also proved to be monodemethyllilopristone (2) and hydrolilopristone(3) by UV,IR,1HNMR and MS.
出处
《中国药物化学杂志》
CAS
CSCD
1997年第4期300-302,310,共4页
Chinese Journal of Medicinal Chemistry
关键词
利洛司酮
分离
鉴别
合成
药物
lilopristone
monodemethylliplopristone
hydrolilopristone
isolation
identification and synthesis