摘要
分别采用１０ｄ递减法和５ｄ递减法用丁丙诺啡对４８０例患者进行戒毒治疗，结果表明：该药治疗期间病人戒断症状控制平稳，撤药反应轻微，未发现丁丙诺啡依赖形成。两种递减法比较结果显示，对于重度依赖患者，１０ｄ疗法优于５ｄ疗法；对于中度和轻度依赖患者，两种疗法无显著性差异；１０ｄ疗法脱毒成功率明显高于５ｄ疗法，二者差异具有显著性意义（Ｐ＜０．０５）。治疗中副作用主要有头痛、疲乏、偶发晕厥。治疗后部分患者出现顽固性失眠等稽延性戒断综合征，这可能是部分依赖患者复吸原因之一。本文结果证明丁丙诺啡是一种安全有效的海洛因依赖治疗药，且采用１０ｄ递减法给药具有更好疗效。
cases of heroin addicts were treated by buprenorphine (Bup) with 10-day or 5-day gradually reducing dosage schedules, and the clinical efficacy was compared between the two schedules. The results showed that during medication adminstration, Bup was stably effective in controling the abstinence syndromes of heroin addicts with slight drug withdrawal symptoms and no Bup dependence was found. It also showed that 10-day schedule was more effective than 5-day schedule in the treatment of patients with severe heroin dependence, but there was no difference in the patients with moderate or light heroin dependence.
关键词
丁丙诺啡
海洛因依赖
递减疗法
戒断症状
buprenorphine
heroin dependence
gradually reducing dosage
abstinence syndrome
