融合蛋白连接肽的研究进展

Research Progress in the Linker of Fusion Protein

融合蛋白是将两个或多个基因的编码区首尾连接,由同一调控序列控制构成的基因表达产物。对于有连接肽的融合蛋白,连接肽的设计在其中起着决定性的作用。该文从连接肽的设计、构建、分类、功能以及用连接肽构建融合蛋白时出现的问题和问题的解决等几个方面作了综述。

Fusion protein was a genetic expression product, which was composed by two or more head- to- tail ligation genic coding region that were controlled by the same regulatory sequence, The design of linker played an important part in the fusion protein with connecting pepfide. Linker designing, linker construction, linker classify, the function of linker, the problem arised and solved in the fusion protein with linker, were reviewed in this article.