菊三七地下部分的化学成分

Chemical constituents of roots of Gynura segetum(Lour.) Merr.

目的：对菊三七Gynura segetum（Lour．）Merr．根的化学成分进行分离和鉴定。方法：采用硅胶柱层析、sephadex LH-20柱层析和重结晶等方法分离纯化，根据理化性质和光谱鉴定化合物的结构。结果：从菊三七乙醇提取物中分离得到11个化合物，分别为：β-谷甾醇（p-sitosterol，1）、千里光宁碱（senecionine，2）、千里光菲灵碱（seneciphylline，3）、菊三七碱乙（E-seneciphylline，4）、seneciphyllic acid（5）、腺苷（adenosine，6）、尿苷（uridine，7）、金丝桃苷（hyperoside，8）、槲皮素（quercetin，9）、琥珀酸（succinicacid10）、β-胡萝卜苷（daucosterol，11）。结论：化合物5—9和11首次从菊三七中分离得到。

Objective:To study the chemical constituents of the underground parts of Gynura segetum(Lour.)Merr..Method:Repeated column chromatography on silica gel and Sephadex LH-20 compounds were used for isolation of chemical constituents of this plant.Structures were elucidated on the basis of spectral analysis and comparison with literature data.Results: Eleven compounds were isolated and identified as β-sitosterol(1),senecionine(2),seneciphylline(3),E-seneciphylline(4),seneciphyllic acid(5),adenosine(6),uridine(7),hyperoside(8),quercetin(9),amber acid(10),daucosterol(11).Conclusion: Compounds 5~9 and 11 have been isolated from this plant for the first time.