老年高血压病患者脉压指数与血清胰岛素样生长因子1水平无关

No Correlation Between Pulse Pressure Index and Serum Insulin-Like Growth Factor-1 in Aged Essential Hypertension Patients

目的探讨老年原发性高血压患者脉压指数与血清胰岛素样生长因子1的关系。方法60岁以上体检者132例,其中高血压病患者99例,健康对照者33例。按脉压指数高低将高血压病患者分为正常脉压指数组(脉压指数≤0.5)57例和高脉压指数组(脉压指数>0.5)42例。检测各组血清胰岛素样生长因子1水平。结果高血压病组血清胰岛素样生长因子1水平与对照组相比无显著差异,高脉压指数组与低脉压指数组之间血清胰岛素样生长因子1水平也无显著差异;直线相关分析显示,高血压病组脉压指数与胰岛素样生长因子1水平无关,对照组脉压指数与胰岛素样生长因子1水平负相关(r=-0.736,P=0.000);多元线性回归分析显示,高血压病组中年龄是脉压指数的独立影响因素(P=0.006),对照组中胰岛素样生长因子1是脉压指数的独立影响因素(P=0.003)。结论老年高血压病患者脉压指数与血清胰岛素样生长因子1水平无关,健康老年人脉压指数与血清胰岛素样生长因子1水平负相关。

Aim To study the association between pulse pressure index （PPI） and serum insulin-hke growth factor-1 （IGF-1） in aged cases with essential hypertension （EH）. Methods To detect serum IGF-1, and to calculate pulse pressure index in 132 aged cases in physical examination. Two groups were divided into EH group （99eases） and control group 133 cases）. The EH group were divided into two sub-groups according to the PPI： normal PPI sub-group （PPI≤0.5） and high PPI sub-group （PPI 〉 0.5）. The difference of the IGF-1 and other data between two groups was compared. The relativity between PPI and other data in two groups was calculated with Pearson linear correlation analysis and multiple linear regression analysis. Results There were no obvious difference of the levels of IGF-1 between two groups and between two sub-groups （ P 〉 0.05）. Pearson linear correlation analysis showed that there was no correlation between PPI and IGF-1 in EH group. Multiple linear regression analysis showed that age was the independent influence factor of PPI （ P = 0. 006 ） in EH group. In control group, Pearson linear correlation analysis showed that there was negative correlation between PPI and IGF-1 （ r = - 0.736, P = 0.000） and multiple linear regression analysis showed that IGF- 1 was the independent influence factor of PPI （ P = 0.003）. Conclusions In aged Eli patients, there was no correlation between PPI and serum IGF-1. In healthy old people, there was negative correlation between PPI and serum IGF-1.