在常规治疗基础上应用卡维地洛治疗慢性心力衰竭并发肾功能不全患者的效果

Carvedilol in treatment of patients with chronic heart failure and chronic renal failure

目的观察在常规治疗基础上应用卡维地洛对慢性心力衰竭(CHF)并发肾功能不全患者的临床疗效。方法采用自身对照的方法,27例CHF并发肾功能不全的患者在接受常规治疗的基础上加用卡维地洛直到目标剂量,比较治疗前及治疗12周后患者的心功能和肾功能。结果治疗12周后患者左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)较治疗前明显缩小(P<0.01),左室射血分数(LVEF)较治疗前显著增高(P<0.01)。治疗12周后血尿素氮(BUN)、肌酐(Cr)、β2-微球蛋白(β2-MG)较治疗前明显降低(P<0.01)。结论在常规治疗基础上应用卡维地洛能明显改善CHF并发肾功能不全患者的心功能和肾功能。

AIM To investigate the clinical effect of carvedilol for patients with chronic heart failure and chronic renal failure. METHODS In addition to regular treatment of digoxin, diuretics and angiotensin- converting enzyme inhibitor, 27 patients were treated with carvedilol gradually to target dosage for 12 weeks. We compared the cadiac function and the renal function before and after the treatment of carvedilol. RESULTS After treatment for 12 weeks, the left ventricular end-diastolic dimension （LVEDD） and left ventricular end-systolic dimension （LVESD） reduced significantly, while the left ventricular ejection fraction （LVEF） increased significantly. The blood urea nitrogen （BUN）, serum creatinine （Cr） and blood β2-microglobulin （β2-MG） decreased significantly. CONCLUSION Carvedilol improves the cadiac function and the renal function of patients with chronic heart failure and chronic renal failure.