电针五脏俞对格林-巴利综合征模型兔坐骨神经电生理功能的影响

Effects of electroacupuncture at shu-points of the five zang-organs on electrophysiologic function of sciatic nerve in the rabbit of Guillain-Barre syndrome

目的:探讨电针膀胱经五脏俞治疗格林-巴利综合征(GBS)的作用机制。方法:选用健康大耳白兔80只,随机分成4组,即空白组、模型组、电针组、免疫球蛋白组,每组各20只。采用国际公认的P2免疫动物模型,电针组采用电针膀胱经五脏俞进行治疗,免疫球蛋白组家兔按每日80mg/kg给予提取的兔免疫球蛋白静脉注射进行治疗。各组分别于第7、14d各评价1次,观察2种方法对GBS家兔坐骨神经运动传导速度(MCV)、F波的影响。结果:急性变态反应性神经炎(EAN)家兔坐骨神经MCV明显减慢,治疗第14d时电针组家兔坐骨神经MCV较模型组明显提高(P<0.01),F波异常例数与模型组相比明显减少(P<0.05)。结论:电针膀胱经五脏俞能提高GBS模型兔坐骨神经MCV,降低坐骨神经异常F波出现率。

Objective To probe into the mechanism of electroacupuncture at shu-points of the five zang-organs for treatment of Guillain-Barre syndrome （GBS）. Methods Eighty healthy giant-ear white rabbits were randomly divided into 4 groups, a blank group, a model group, an electroacupuncture （EA） group and an immunoglobulin group, 20 rabbits in each group. The internationally recognized P 2 immune rabbit model was used in the study. The EA group were treated with EA at shu-points of the five zang-organs and the immunoglobulin group with intravenous injection of immunoglobulin 80 mg/kg/day. The sciatic nerve movement conduction velocity （MCV） and F wave incidence rate were investigated respectively at the 7th and 14th days of treatment in the rabbits of GBS. Results The sciatic nerve MCV significantly reduced in the model group, and it significantly increased （P〈0.01） and F wave abnormal cases was significantly reduced （P〈0. 05） after treatment for 14 days in the EA group as compared with those in the model group. Conclusion EA at shu-points of the five zang-organs can increase the sciatic nerve MCV and decrease the abnormal F wave incidence rate of the sciatic nerve in the rabbit of GBS.