紫外线减毒弓形虫免疫对小鼠旋毛虫感染肌肉组织病理的影响

Immunization with UV-Attenuated Toxopalsma gondii Influences Pathology of Muscular Trichinella spiralis in Mouse Model

目的探讨紫外线减毒弓形虫免疫对小鼠旋毛虫感染肌肉期组织病理的影响。方法ICR小鼠分为两组,实验组为紫外线减毒弓形虫免疫3周后再感染旋毛虫,对照组为旋毛虫单独感染。结果与旋毛虫单感染相比,小鼠预先经紫外线减毒弓形虫免疫再感染旋毛虫后23d,其肌肉期幼虫周围的炎症细胞浸润明显减轻,肌肉组织的病理损伤也明显减轻。结论紫外线减毒弓形虫免疫对小鼠旋毛虫感染肌肉期的组织病理有一定的免疫调节作用。

Objective To investigate the possible influence of the immunological environment created by immunization with UV-attenuated Toxoplasma gondii in the development of Trichinella spiralis of muscle phase in mouse models. Methods Mice of experimental group were immunized with UV-attenuated T. gondii, then infected with T. spiralis ; mice infected with T. spiralis alone as control. Results There were significant higher adult worm burdens in the small intestine and lower larva burdens in muscle tissues. Conclusion Mice immunized with UV-attenuated T. gondii could limit the inflammation of muscular T. spiralis infection.