宫颈癌组织中蛋白酶活化受体-1的表达与盆腔淋巴结转移的关系

Relationship between PAR-1 Expression and Pelvic Lymphatic Metastasis in Cervical Carcinoma

目的:探讨宫颈癌组织中蛋白酶活化受体-1(PAR-1)的表达与盆腔淋巴结转移的关系。方法:采用免疫组织化学方法,检测PAR-1在宫颈鳞癌组织(35例)、腺癌组织(25例)及正常组织(20例)中的表达情况。结果:PAR-1在正常宫颈组织中不表达,在宫颈癌组织中有较高的阳性表达(P<0.01),有淋巴转移的癌组织中PAR-1的阳性表达率明显高于无淋巴转移的癌组织(P<0.01)。结论:PAR-1在宫颈癌组织中的表达与盆腔淋巴结转移密切相关。

Objective： To investigate the relationship between the PAR-1 expression and pelvic lymphatic metastasis in cervical carcinoma. Methods： Immunohistochemistry method was used to detect the expresion of PAR-1 in 35 cases of cervical squamous cell carcinoma, 25 cases of cervical adenocarcinoma, and 20 cases of normal cervical specimen. Results： The expression of PAR-1 was negative in normal cervical tissues, but the positive expression rate of PAR-1 was 41.67% in cervical invasive carcinoma, PAR-1 positive expression rate in carcinoma was correlated to pelvic lymphatic metastasis. Conclusion： PAR-1 may play an importment role in the pelvic lymphatic metastasis in cervical carcinoma.