大肠癌防治的分子靶点进展
摘要
随着国人饮食习惯的西化，我国大肠癌的发病率呈上升趋势，目前已占恶性肿瘤发病率的第4—6位。若有一些特异性和选择性的分子作为预防和治疗的靶点，则可对公共卫生防御措施的制定和实施起到很大的作用。近年来，随着肿瘤发病机制研究的进展，已有越来越多这样的分子靶点被发现，并且有些已进人或即将进入临床实践。
出处
《中华消化内镜杂志》
2008年第6期333-334,共2页
Chinese Journal of Digestive Endoscopy
参考文献13
-
1Chan AT, Ongino S, Charles SF. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. New Eng J Med,2007, 356 : 2131-2142.
-
2Aurelie T, Christophe F, Nicole Pet al. Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity. Anti Cancer agents Med Chem, 2006, 6:187-208.
-
3Sinicrope FA, Half E, Morris JS, et al. Cell proliferation and apoptotic indices predict adenoma regression in a placebo-controlled trial of celecoxib in familial adenomatous polyposis patients. Cancer Epidemiol Biomarkers Prey,2004,13:920-927.
-
4Reddy BS. Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. Environ Mol Mutagen, 2004,44:26-35.
-
5Jacobs EJ, Rodriguez C, Brady KA, et al. Cholesterol-lowering drugs and colorectal cancer incidence in a large united states coholt. JNCI J Nati Can Institute,2006, 98:69-72.
-
6Swamy MV, Cooma I, Reddy BS, et al. Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens, Int J Oncol, 2002,20:753-759.
-
7Jassam N, Bell SM, Speirs V, et al. Loss of expression of oestrogen receptor betacolon cancer and its association with Dukes'staging. Oncol Rep, 2005, 14 : 17-21.
-
8Picariello L, Fiorelli G, Martineti V, et al. Growth response of colon cancer cell lines to selectve estrogen receptor modulators. Anticancer Research, 2003, 23: 2419-2424.
-
9Fang JY, Xiao SD. Alteration of DNA methylation in gastrointestinal carcinogenesis. J Gastroenterol Hepatol, 2001,16:960-968.
-
10Pufulete M, AI-Ghnaniem R, Khushal A, et al. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut, 2005,54:648 653.
-
1许惠丽.急性淋巴细胞白血病免疫表型特点及临床意义[J].中国现代药物应用,2016,10(10):30-31.
-
2王华.直肠超声在前列腺癌早期诊断中的应用[J].中国煤炭工业医学杂志,2010,13(1):105-106.
-
3沈志远(综述),孙忠全(审校).机器人辅助腹腔镜下前列腺癌根治手术的相关问题[J].中国男科学杂志,2013,27(9):67-69. 被引量：6
-
4李悠然,谷云飞.微卫星不稳定在结直肠癌的研究进展[J].重庆医学,2016,45(13):1855-1859. 被引量：6
-
5罗新春.克林霉素不良反应与预防措施[J].中国医药指南,2010,8(31):106-107. 被引量：1
-
6张丽,赵保荣,王爱芹.复方口服避孕药与肿瘤发病的关系[J].山东医药,1997,37(11):34-34. 被引量：1
-
7梁晓雯,杨友林,陈蕾.碘造影剂的过敏反应及防范措施[J].山西医药杂志（上半月）,2013,42(6):700-701. 被引量：6
-
8金晶,戚庭月.超声造影在前列腺癌诊疗中的研究进展[J].中华泌尿外科杂志,2015,36(10):798-800. 被引量：2
-
9郭伟,曾庆华,王存玉.头颈肿瘤防治的新靶点环氧酶的研究进展[J].中华口腔医学杂志,2004,39(3):261-263. 被引量：4
-
10周杰明.完善国家基本药物工作,推进国家药物政策的制定和实施[J].中国药事,2005,19(3):131-133. 被引量：9
