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RD1／ESX-1分泌系统与结核分枝杆菌的毒力和致病性 被引量：1

RD1/ESX-1 secretion system for the virulence and pathogenisis of Mycobacterium tuberculosis
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摘要 结核分枝杆菌（MTB）全基因序列测定的完成和比较基因组学的发展，使得对MTB毒力和致病机制的认识不断深入，近年发现RD1区在MTB的致病机制中充当重要角色，而RD1区编码的ESX-1蛋白组成的分泌转运系统与MTB的毒力关系密切。此文主要从MTBRD1／ESX-1蛋白分泌转运系统对ESAT-6／CFP-10分泌输出的影响，探讨其与MTB的毒力和致病机制的关系。 The availability on the complete genome sequence of M. tuberculosis （MTB） and the development of the comparative genomics, have led to important advances in understanding the pathogenesis of tuberculosis. An important role with RD1 of genome in MTB pathogenesis has been demonstrated, and the secretion-transport system which is composed of KSX-1 proteins encoded by MTB RD1 locus is in close relation with the virulence of MTB. This text mainly describes the influence of the secretion-transport system of MTB RD1/KSX-1 on the secretion and export of KSAT-6/CFP-10, so as to investigate the relation between the secretion-transport system and the virulence and pathogenesis of MTB.
作者 秦紫芳 鲍朗
机构地区 四川大学华西基础医学与法医学院感染与免疫研究室
出处 《国际流行病学传染病学杂志》 CAS 2008年第3期178-181,I0004,共5页 International Journal of Epidemiology and Infectious Disease
基金 国家自然科学基金（30271172）
关键词 分枝杆菌 结核 毒力蛋白分泌 RD1 ESX-1 Mycobacterium tuberculosis Virulence proteins secretion RD1 KSX-1
分类号 R3 [医药卫生—基础医学]
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参考文献20

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同被引文献25

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国际流行病学传染病学杂志
2008年 第3期

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