B7家族共刺激分子与机体对乙型肝炎病毒感染的免疫耐受

Costimulatory molecules of B7 family and immune tolerance of human body to hepatitis B virus infection

机体对HBV的免疫耐受是HBV感染慢性化的主要机制。共刺激分子是控制免疫应答的开关。田家族共刺激分子是最基本的共刺激分子，在HBV感染中可提供细胞活化所需要的第二信号，决定T细胞是活化增殖还是转为无能状态，对机体的免疫耐受起重要作用。了解田家族共刺激分子在HBV感染免疫应答中的作用，对揭示HBV感染免疫耐受机制有重要的意义。

Immune tolerance to HBV is the major chronicity mechanism of HBV infection. Costimulatory molecules play key roles in immune response. B7 family members are the most common costimulatory molecules that can provide a second message to the primary T cells and activate T cells. It is of great importance in the research of immunopathogenesis of HBV infection to understand the role of B7 family in the immune response.