性激素替代疗法在年轻宫颈鳞癌术后患者中的应用

The application of hormone replacement therapy in young patients of cervical squamous cell cancer

目的观察性激素替代疗法在年轻宫颈鳞癌术后患者中的应用。方法放免法分别检测利维爱组、倍美力组及安慰剂组血中雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)含量,生化仪检测血中胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)含量。双能X线骨密度仪测量三组冶疗前后腰椎L2-4侧位骨密度(BMD)。结果用药后利维爱组、倍美力组E2及BMD较安慰剂组显著升高,而FSH、HL较安慰剂组显著降低。利维爱组TC、TG明显低于安慰剂组。结论性激素替代疗法有效改善年轻宫颈鳞癌术后患者绝经综合征,提高患者生存质量。与传统雌激素相比,利维爱具有独特优点。

Objective To observe the appilcation of hormone replacement therapy in young patients of cervical squamous cell cancer. Methods The levels of E2FSH and LH were evaluated by RI method. The levels of TC,TG, LDL and HDL were determined by automatic biochemistry analyzer. The bone mineral density of lumbar vertebra was measured by dual energy X-ray absorptionmetry. Results Compared with placebo, the levels of E2 and BMD were singnificantly high in the group of Tibolong and Conjugated Estogens, but the levels of FSH and LH wrer low. Conclusion HRT improves climacteric syndrome efficiently in young patients of cervical squamous cell cancer.