豚鼠噪声暴露后畸变产物耳声发射及听神经动作电位的变化(论著)

Changes of distortion product otoacoustic emission and action potential following noise exposure in guinea pigs

目的：观察豚鼠暴露于模拟舰船机舱噪声后畸变产物耳声发射（ＤＰＯＡＥ）及听神经动作电位（ＡＰ）的变化。方法：选用１６只豚鼠，分为即刻、７天及正常对照３组。噪声强度为１１５ｄＢ（Ａ），连续暴露４小时。于暴露噪声前后自身对照测试ＤＰＯＡＥ听力图，Ｉ／Ｏ曲线及ＡＰ。结果：噪声暴露后即刻组ＤＰＯＡＥ振幅明显下降，ＡＰ阈值提高，７天后ＤＰＯＡＥ振幅基本恢复至噪声暴露前基线。结论：ＤＰＯＡＥ可明确显示耳蜗毛细胞功能，较ＡＰ测定耳蜗功能损伤与否更有意义，它具有频率特性，可客观说明耳蜗受损部位。

Aim:To observe the changes of distortion product otoacoustic emission(DPOAE) and action potential (AP) after the exposure to a simulated naval ship engineroom noise.Methods:Sixteen healthy Preyer′s reflex normal guinea pigs were divided into 3 groups(namely,the immediate,7 d and normal control groups).The intensity of the noise was 115 dB(A),and the exposure was 4h continuously.The DPOAE audiogram,DPOAE I/O function and AP were measured before,immediately and 7 days after noise exposure.Results:DPOAE amplitude decreased and the threshold of AP increased both significantly immediately after the noise exposure.Seven days after the exposure,DPOAE amplitude recovered to preexposure baseline and AP also recovered to preexposure threshold.Conclusion:DPOAE can reflect the function of outer hair cells more significantly than AP does.DPOAE has the specificity of frequency and therefore can indicate objectively the damaged site of the cochlea.