山莨菪碱对烫伤大鼠血管通透性变化的影响

Effects of Anisodamine on Permeability of Microvessels in Post-Burn Rats

山莨菪碱对烫伤大鼠血管通透性变化的影响谢建军１林国成２姚秀娟１贾敏１杨瑟飞３赵德化１烧伤后血管通透性的改变是引起组织水肿和内环境紊乱的病理学基础。如何阻止或逆转血管通透性的改变，减轻水肿形成，已成为烧伤的重要研究内容之一。已发现山莨菪碱能减轻大鼠烧伤...

o evaluate the effects of anisodamine(6542) on the changes of permeability of microvessels on post-burn rats.125Ialbumin(RISA) and wet weight/dry weight were measured to definite the permeability of microvessels of several tissues and organs on the model of Ⅲ degree burn injury on 25% total body surface area(TBSA) in rats.Results:The increasing of the RISA was observed in saline control group that not only the skin and the muscles which were directly burned but also the organs such as lung and kidney, and the increasing of water content was observed just in the skin, muscle and lung.6542(5mg/kg) could distinctly reduce these changes respectively(P<0.05￣0.01) compared to the saline control group.6542 could inhibit the increasing of permeability of microvessels of several tissues and organs in postburn rats.