摘要
62例功能性消化不良（FD）患者随机分为胃舒康治疗组32例和吗丁啉组30例．治疗1月.分别观察其疗效及对治疗前后血浆盲动素（MTL）、血清抗幽门螺杆菌抗体（抗HPIgG）的影响。结果：治疗组的近期临床治愈率为43．8％，总有效率为93．8％．优于吗丁啉组的16.7％、80.0％（P＜0．05）。治疗后治疗组血浆MTL阻显升高，血清抗HPIgG显著下降．与治疗前相比有显著性差异（P＜0．01）；而吗了批组MTL水平、掠HPIgG滴度较治疗前均无明显变化（P＞0.05）、提示胃舒康治疗FD取得较好疗效的机制可能是促进内源性MTL释放．从而加速胃排空和清除HP.
62 patients with functional dyspepsia (FD) were divided randomly into two groups:in therapeutic group 32 cases were trcated with Weishukang and in control group 30 cnses treatedwith Motilium for one month. Therapeutic effect of two medicines and their effect on plasmamotilin(MTL ) and serum anti-helicobacter pylon immunoglobulin (anti-HP IgG ) were observedbefore and after treatment. Results: in therapeutic group recent clinical cure rate is 43. 8%. totaleffective rate is 93. 8%. Those ratcs are better than that in control group (16. 7%. 80. 0%.respectively ) (P<0. 05). After treatment, plasma MTL higher and serum anti-HP IgG was lowerthan before treatment in the therapeutic group. There were significant difference before and aftertreatment (P0.01 ). But in control group MTL level and titcr of anti-HP IgG has not evidentchange be fore and after treatment (P > 0. 05 ). Our results suggest that mechanism ofWeishukang is to promote release of endogenous MTL, therefore to hasten emptying stomach andcleaning HP.
关键词
胃舒康
消化不良
中药
胃动素
幽门螺杆菌
抗体
weshukang
functional dyspepsia
motilin
helicobacter pylori
motilium
