环(L-组-L-脯)二肽的合成

Synthesis of cyclodipeptide cyclo(L-His-L-Pro)

许多环二肽具强的生理活性,以N-叔丁氧羰基-L-组氨酸和L-脯氨酸甲酯盐酸盐为原料,经DCC缩合得直链二肽,再经HCl/Et2O脱Boc保护,弱碱性条件下成环,得环(L-组-L-脯)二肽.结构经ESI-MS、IR、1H NMR、13C NMR等表征.

Many cyclodipeptides have strong physiological activities. Cyclo（L-His-L-Pro） was synthesized from protected N- tertbutyloxycarbonyl-L-histidine and L-proline methyl ester hydrochloride via DCC condensation, deprotection of tertbutyloxycarbonyl group with another solution of hydrogen chloride, cyclization with NaHCO3 solution. The structure is identified by ESI-MS , IR, 1H NMR and 13C NMR.