头颈部淋巴结转移性癌中EBER1的原位杂交检测

EBER1 DETECTION ON METASTATIC CARCINOMAS OF CERVICAL LYMPH NODES BY HYBRIDIZED IN SITU METHOD

本研究对包括鼻咽癌７例，涎腺恶性淋巴上皮病４例和口腔各部位不同分化的鳞状细胞癌５例在内的１６例肿瘤的原发灶和其淋巴结转移灶中的ＥＢＥＲ１进行了原位杂交检测，旨在揭示头颈部转移性癌中ＥＢＶ阳性表达在判断其原发肿瘤来源中的意义。结果表明：在头颈部淋巴结转移性癌中发现非角化型的癌并伴有ＥＢＥＲ１阳性者，可提示其原发灶可能来自于鼻咽癌和涎腺恶性淋巴上皮病。

n order to revealed the significance of EBER1 positive expression on head and neck metastatic foci of lymph nodes; the 16 cases of neoplasm including 7 cases of,4 cases of and 5 cases of squamous cell carcinoma with varied differentiation were detected by hybridized in situ on the primary neoplasm and their metastatic foci. Our results suggested that EBV detected in non-keratinizing metastatic carcinomas of cervical lymph nodes can lead to their primary sites coming from nasopharyngeal carcinoma and malignant lymphoepithelioma of salivary glands.